ERCC1

Across TCGA patient cohorts, ERCC1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,309 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERCC1-associated genes across cancer lineages are ERCC4, ZNF263, and RRN3. Each is linked with ERCC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ERCC1-to-partner and partner-to-ERCC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC1 versus ERCC4 in OV, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC1→partner) and Y-score (partner→ERCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ERCC4 →	+0.629	+0.583	<.001	<.001	3	6
LSCC	ZNF263 →	+0.407	+0.229	<.001	.001	3	4
BRCA	RRN3 →	+0.480	+0.214	<.001	<.001	3	4
BRCA	POLR3E →	+0.575	+0.228	<.001	.007	3	4
BRCA	PALB2 →	+0.544	+0.318	<.001	<.001	3	4
LSCC	ZNF48 →	+0.639	+0.238	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,309 associations by consensus.

ERCC1 vs ERCC4 — OV

Explore this scatter interactively →