ERCC1

Across TCGA patient cohorts, ERCC1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC1-associated genes across cancer lineages are ASNS, ATM, and EGFR_pY1068. Each is linked with ERCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC1-to-partner and partner-to-ERCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ERCC1-low versus ERCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC1→partner) and Y-score (partner→ERCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.638	+2.584	<.001	.010	3	2
UCEC	ATM →	-0.600	-2.222	.001	.011	3	2
UCEC	EGFR_pY1068 →	-0.237	-3.321	.026	.009	3	1
UCEC	eIF4E →	+0.266	+4.000	.002	<.001	3	1
UCEC	FoxM1 →	+0.230	+2.222	.036	.011	3	1
UCEC	IGFBP2 →	-0.731	-2.222	.008	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by ERCC1 expression — UCEC

Explore this box plot interactively →