ERCC1

Across TCGA cell cohorts, ERCC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC1-associated GO terms across cancer lineages are Regulation of protection from non-homologous end joining at telomere, Negative regulation of protection from non-homologous end joining at telomere, and Telomeric DNA-containing double minutes formation. Each is linked with ERCC1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ERCC1-to-partner and partner-to-ERCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protection from non-homologous end joining at telomere grouped by ERCC1-low versus ERCC1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC1→partner) and Y-score (partner→ERCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of protection from non-homologous end joining at telomere →	+0.147	+0.793	<.001	<.001	3	12
LARGE_INTESTINE	Negative regulation of protection from non-homologous end joining at telomere →	+0.147	+0.793	<.001	<.001	3	12
LARGE_INTESTINE	Telomeric DNA-containing double minutes formation →	+0.147	+0.793	<.001	<.001	3	12
URINARY_TRACT	Positive regulation of focal adhesion assembly →	+0.123	+0.884	.002	.002	3	11
URINARY_TRACT	Negative regulation of telomere maintenance in response to DNA damage →	+0.104	+1.139	.003	.002	3	9
LIVER	Regulation of cilium assembly →	+0.056	+0.997	.003	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,224 associations by consensus.

Regulation of protection from non-homologous end joining at telomere by ERCC1 expression — LARGE_INTESTINE

Explore this box plot interactively →