Across TCGA patient cohorts, ERC2 mutation is significantly associated with the RNA expression of many other genes, with 6,346 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERC2-associated genes across cancer lineages are CDC37, MFSD12, and RFC5. Each is linked with ERC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERC2-to-partner and partner-to-ERC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERC2→partner) and Y-score (partner→ERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CDC37 →	+0.467	+3.359	<.001	.004	3	5
UCEC	MFSD12 →	+0.340	+2.648	.001	<.001	3	5
UCEC	RFC5 →	+0.458	+1.901	<.001	<.001	3	5
UCEC	ZWINT →	+0.726	+1.847	<.001	<.001	3	4
UCEC	CCSAP →	+0.475	+2.467	<.001	<.001	3	4
UCEC	MAPKAPK5-AS1 →	+0.423	+1.669	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,346 associations by consensus.

Exploration

ERC2 survival (RNA) · tumor vs normal (RNA) · all ERC2 data types