Across TCGA patient cohorts, ERC2 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERC2-associated genes across cancer lineages are TFRC, ASNS, and C-Raf. Each is linked with ERC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERC2-to-partner and partner-to-ERC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERC2→partner) and Y-score (partner→ERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.506	+2.906	.001	.001	3	3
COAD	ASNS →	+0.604	+3.000	<.001	.035	3	3
UCEC	C-Raf →	+0.108	+1.440	.010	.022	3	3
UCEC	4E-BP1 →	+0.346	+3.351	<.001	<.001	2	3
SKCM	14-3-3_beta →	-0.075	-0.839	.022	.035	3	2
UCEC	EGFR →	-0.131	-1.584	.005	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Exploration

ERC2 survival (RNA) · tumor vs normal (RNA) · all ERC2 data types