Across TCGA cell cohorts, ERC2 mutation is significantly associated with the RNA expression of many other genes, with 484 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERC2-associated genes across cancer lineages are ZBTB8A, ZNF596, and ZNF575. Each is linked with ERC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERC2-to-partner and partner-to-ERC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERC2→partner) and Y-score (partner→ERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZBTB8A →	+0.693	+3.321	<.001	.002	3	2
LARGE_INTESTINE	ZNF596 →	+0.595	+2.158	.004	.004	3	2
LARGE_INTESTINE	ZNF575 →	+0.383	+2.389	.006	.006	3	2
LARGE_INTESTINE	P4HTM →	+0.602	+2.652	.005	.001	3	2
PANCREAS	KRTAP1-3 →	+0.038	+5.000	<.001	.006	3	1
PANCREAS	USP17L17 →	+0.013	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 484 associations by consensus.

Exploration

ERC2 survival (RNA) · tumor vs normal (RNA) · all ERC2 data types