ERC1

Across TCGA pan-cancer cohorts, ERC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ERC1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ERC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ERC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where ERC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.344	.009	18	view →
LUAD	OS	Tertile	III,IV	0.534	1.000	.006	18	view →
UCEC	OS	Median	II,III,IV	0.620	1.000	.011	4	view →
CCRCC	DFS	Tertile	III,IV	0.830	0.198	.024	3	view →
LSCC	DFS	Median	All	0.953	0.916	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ERC1–HNSC (OS)

Open the HNSC breakdown →