ERC1

Across TCGA cell cohorts, ERC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,729 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERC1-associated GO terms across cancer lineages are Maintenance of presynaptic active zone structure, Regulation of nucleotide-excision repair, and Transcription initiation-coupled chromatin remodeling. Each is linked with ERC1 in more than 18 cancer types. Because this analysis shows association rather than direction, both ERC1-to-partner and partner-to-ERC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of presynaptic active zone structure grouped by ERC1-low versus ERC1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERC1→partner) and Y-score (partner→ERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Maintenance of presynaptic active zone structure →	+1.550	+1.748	<.001	<.001	3	19
STOMACH	Regulation of nucleotide-excision repair →	+0.129	+1.180	.002	<.001	3	16
STOMACH	Transcription initiation-coupled chromatin remodeling →	+0.096	+1.408	.001	.004	3	16
STOMACH	Endosomal transport →	+0.069	+1.377	.002	.007	3	15
PANCREAS	Positive regulation of mitotic cytokinesis →	+0.170	+1.525	<.001	<.001	3	15
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.071	+1.272	.004	.008	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,729 associations by consensus.

Maintenance of presynaptic active zone structure by ERC1 expression — LUNG_NSCLC_LUSC

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