ERC1

Across TCGA cell cohorts, ERC1 mutation is significantly associated with the RNA expression of many other genes, with 300 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERC1-associated genes across cancer lineages are ACER1, KRT9, and SEL1L2. Each is linked with ERC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERC1-to-partner and partner-to-ERC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by ERC1-low versus ERC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERC1→partner) and Y-score (partner→ERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.087	+2.408	<.001	.004	3	2
BLOOD_Lymphoma	KRT9 →	+0.050	+4.191	<.001	.007	3	1
LUNG_NSCLC_LUAD	SEL1L2 →	+0.027	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	BHLHE23 →	+0.044	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.023	+4.662	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SLITRK2 →	+0.801	+3.605	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 300 associations by consensus.

ACER1 by ERC1 expression — LARGE_INTESTINE

Explore this box plot interactively →