ERBIN

Across TCGA pan-cancer cohorts, ERBIN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ERBIN data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ERBIN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ERBIN expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and UCEC are the cancer types where ERBIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.825	0.416	.002	29	view →
HNSC	DFS	Median	IV	0.859	0.524	<.001	17	view →
UCEC	DFS	Median	II,III,IV	0.877	0.530	.019	16	view →
GBM	OS	Quartile	All	0.202	0.604	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ERBIN–LUAD (OS)

Open the LUAD breakdown →