ERBIN

Across TCGA cell cohorts, ERBIN mutation is significantly associated with the RNA expression of many other genes, with 223 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERBIN-associated genes across cancer lineages are ADNP2, GDPD1, and ZNF691. Each is linked with ERBIN in more than 1 cancer types. Because this analysis shows association rather than direction, both ERBIN-to-partner and partner-to-ERBIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by ERBIN-low versus ERBIN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBIN→partner) and Y-score (partner→ERBIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADNP2 →	+0.620	+3.628	.007	<.001	3	2
BLOOD_Leukemia	GDPD1 →	+0.790	+2.503	.008	.005	3	2
BLOOD_Leukemia	ZNF691 →	+0.385	+3.366	.007	.002	3	2
BLOOD_Leukemia	PRKCQ →	+1.372	+2.614	.005	.003	3	2
BLOOD_Myeloma	CD300H →	+0.256	+4.285	.001	.003	3	1
OESOPHAGUS	MTNR1B →	+0.139	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 223 associations by consensus.

ADNP2 by ERBIN expression — LARGE_INTESTINE

Explore this box plot interactively →