ERBB4

Across TCGA patient cohorts, ERBB4 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,698 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ERBB4-associated proteins across cancer lineages are PPP1R12B, RPS2, and RSL1D1. Each is linked with ERBB4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERBB4-to-partner and partner-to-ERBB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERBB4 versus PPP1R12B in HNSC, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB4→partner) and Y-score (partner→ERBB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R12B →	+0.789	+0.671	<.001	<.001	3	7
PDAC	RPS2 →	-0.283	-0.366	<.001	<.001	3	6
BRCA	RSL1D1 →	-0.655	-2.192	<.001	<.001	3	6
BRCA	SORBS1 →	+0.561	+1.215	<.001	.003	3	6
HNSC	SORBS1_S556 →	+0.911	+0.616	<.001	<.001	3	6
HNSC	SORBS2 →	+0.604	+0.797	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,698 associations by consensus.

ERBB4 vs PPP1R12B — HNSC

Explore this scatter interactively →