ERBB4

Across TCGA patient cohorts, ERBB4 protein abundance is significantly associated with the RNA expression of many other genes, with 7,031 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ERBB4-associated genes across cancer lineages are ABCG2, SCGB1D2, and LINC01750. Each is linked with ERBB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERBB4-to-partner and partner-to-ERBB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERBB4 versus ABCG2 in GBM, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB4→partner) and Y-score (partner→ERBB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ABCG2 →	+0.951	+0.453	<.001	<.001	3	3
BRCA	SCGB1D2 →	+3.442	+0.740	<.001	.004	3	3
BRCA	LINC01750 →	+0.460	+0.809	<.001	<.001	3	3
UCEC	MTND2P23 →	+1.225	+0.812	<.001	<.001	3	3
UCEC	MTCO1P46 →	+1.118	+0.763	<.001	<.001	3	3
OV	SH3BP1 →	-0.612	-0.739	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,031 associations by consensus.

ERBB4 vs ABCG2 — GBM

Explore this scatter interactively →