ERBB4

Across TCGA patient cohorts, ERBB4 mutation is significantly associated with the total protein of many other genes, with 117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERBB4-associated genes across cancer lineages are Cyclin-B1, ASNS, and MIG-6. Each is linked with ERBB4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERBB4-to-partner and partner-to-ERBB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ERBB4-low versus ERBB4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB4→partner) and Y-score (partner→ERBB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Cyclin-B1 →	+0.771	+3.000	.011	.038	3	7
LUAD	ASNS →	+0.349	+2.000	.033	.027	3	6
BRCA	MIG-6 →	+0.292	+3.005	<.001	.020	3	5
BRCA	Caveolin-1 →	-1.189	-3.000	.003	.037	3	5
STAD	TFRC →	+0.491	+3.000	.023	.033	3	4
UCEC	PCNA →	+0.166	+1.347	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

Cyclin-B1 by ERBB4 expression — BRCA

Explore this box plot interactively →