ERBB4

Across TCGA cell cohorts, ERBB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,723 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ERBB4-associated GO terms across cancer lineages are Urokinase plasminogen activator signaling pathway, Positive regulation of DNA recombination, and Regulation of monoatomic cation transmembrane transport. Each is linked with ERBB4 in more than 5 cancer types. Because this analysis shows association rather than direction, both ERBB4-to-partner and partner-to-ERBB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Urokinase plasminogen activator signaling pathway grouped by ERBB4-low versus ERBB4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB4→partner) and Y-score (partner→ERBB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Urokinase plasminogen activator signaling pathway →	-0.553	-1.763	.003	<.001	3	6
OVARY	Positive regulation of DNA recombination →	+0.062	+1.662	.003	<.001	3	6
BONE	Regulation of monoatomic cation transmembrane transport →	-0.058	-0.860	.001	<.001	3	6
BONE	Regulation of chondrocyte differentiation →	-0.117	-0.635	<.001	.004	3	6
PANCREAS	Potassium ion transmembrane transport →	-0.049	-0.100	<.001	.005	2	6
SOFT_TISSUE	Mammary gland alveolus development →	-0.269	-1.158	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,723 associations by consensus.

Urokinase plasminogen activator signaling pathway by ERBB4 expression — OVARY

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