ERBB4

Across TCGA cell cohorts, ERBB4 mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERBB4-associated genes across cancer lineages are PLA2G6, LY6G6F, and CLEC14A. Each is linked with ERBB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERBB4-to-partner and partner-to-ERBB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G6 grouped by ERBB4-low versus ERBB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB4→partner) and Y-score (partner→ERBB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G6 →	+0.707	+2.364	.004	<.001	3	3
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	2
LUNG_SCLC	CLEC14A →	+0.079	+2.954	.003	.005	3	2
URINARY_TRACT	TEX43 →	+0.097	+4.087	<.001	.009	3	2
URINARY_TRACT	OR2L3 →	+0.005	+4.087	<.001	.009	3	2
LUNG_NSCLC_LUAD	AGTPBP1 →	+0.610	+3.137	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

PLA2G6 by ERBB4 expression — LARGE_INTESTINE

Explore this box plot interactively →