ERBB3

Across TCGA pan-cancer cohorts, ERBB3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ERBB3 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ERBB3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ERBB3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where ERBB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	1.000	0.794	.011	29	view →
LSCC	DFS	Median	III,IV	0.860	0.434	.006	19	view →
PDAC	OS	Quartile	All	0.773	0.377	.019	11	view →
OV	DFS	Median	All	1.000	0.831	.030	4	view →
HNSC	OS	Tertile	All	0.932	1.000	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ERBB3–CCRCC (OS)

Open the CCRCC breakdown →