ERBB3

Across TCGA patient cohorts, ERBB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,696 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERBB3-associated proteins across cancer lineages are ERBB3_S686, LLGL2, and SGTB. Each is linked with ERBB3 in more than 7 cancer types. Because this analysis shows association rather than direction, both ERBB3-to-partner and partner-to-ERBB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERBB3 versus ERBB3_S686 in GBM, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB3→partner) and Y-score (partner→ERBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERBB3_S686 →	+1.039	+1.867	<.001	<.001	3	8
BRCA	LLGL2 →	+0.448	+0.908	<.001	<.001	3	7
LSCC	SGTB →	-0.320	-0.919	<.001	<.001	3	6
BRCA	CEP170 →	-0.282	-1.016	<.001	<.001	3	6
CCRCC	CTNND1 →	+0.256	+1.684	<.001	<.001	3	6
BRCA	FNDC3B →	-0.398	-0.752	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,696 associations by consensus.

ERBB3 vs ERBB3_S686 — GBM

Explore this scatter interactively →