ERBB3

Across TCGA patient cohorts, ERBB3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,174 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ERBB3-associated genes across cancer lineages are BAG2, IL2RA, and MSN. Each is linked with ERBB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERBB3-to-partner and partner-to-ERBB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERBB3 versus BAG2 in CCRCC, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB3→partner) and Y-score (partner→ERBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BAG2 →	-0.705	-0.302	<.001	.008	3	5
BRCA	IL2RA →	-1.168	-0.441	<.001	<.001	3	5
BRCA	MSN →	-0.670	-0.386	<.001	<.001	3	5
OV	CHST11 →	-0.730	-0.481	.002	.005	3	5
HNSC	LINC00632 →	-0.990	-0.459	.002	.001	3	5
HNSC	PABPC4L →	-0.660	-0.245	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,174 associations by consensus.

ERBB3 vs BAG2 — CCRCC

Explore this scatter interactively →