ERBB3

Across TCGA patient cohorts, ERBB3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERBB3-associated genes across cancer lineages are ATM, 4E-BP1, and P-Cadherin. Each is linked with ERBB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERBB3-to-partner and partner-to-ERBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ERBB3-low versus ERBB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB3→partner) and Y-score (partner→ERBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.389	-1.643	.001	.002	3	3
UCEC	4E-BP1 →	+0.273	+2.137	<.001	<.001	3	3
STAD	P-Cadherin →	-0.170	-3.169	.003	.018	3	2
COAD	Caspase-7-cleavedD198 →	+1.079	+3.708	.001	<.001	1	4
BRCA	PEA-15 →	-0.230	-2.321	.010	.037	3	2
SKCM	ER-alpha →	-0.180	-3.157	.037	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by ERBB3 expression — UCEC

Explore this box plot interactively →