ERBB3

Across TCGA cell cohorts, ERBB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,633 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ERBB3-associated GO terms across cancer lineages are Establishment of epithelial cell apical/basal polarity, Intracellular transport of virus, and Acetylcholine biosynthetic process. Each is linked with ERBB3 in more than 13 cancer types. Because this analysis shows association rather than direction, both ERBB3-to-partner and partner-to-ERBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of epithelial cell apical/basal polarity grouped by ERBB3-low versus ERBB3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB3→partner) and Y-score (partner→ERBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Establishment of epithelial cell apical/basal polarity →	-0.246	-3.110	<.001	<.001	3	14
BREAST	Intracellular transport of virus →	-0.166	-2.682	<.001	<.001	3	11
PANCREAS	Acetylcholine biosynthetic process →	+1.648	+2.726	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.167	+1.847	<.001	<.001	3	11
BREAST	Transport of virus →	-0.166	-2.682	<.001	<.001	3	11
BREAST	Positive regulation of establishment of T cell polarity →	-0.222	-2.689	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,633 associations by consensus.

Establishment of epithelial cell apical/basal polarity by ERBB3 expression — PANCREAS

Explore this box plot interactively →