ERBB3

Across TCGA cell cohorts, ERBB3 mutation is significantly associated with the RNA expression of many other genes, with 797 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERBB3-associated genes across cancer lineages are CFC1B, ISM1, and METTL4. Each is linked with ERBB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERBB3-to-partner and partner-to-ERBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFC1B grouped by ERBB3-low versus ERBB3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB3→partner) and Y-score (partner→ERBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CFC1B →	+0.016	+4.247	<.001	.004	3	2
LARGE_INTESTINE	ISM1 →	+0.735	+2.628	.004	.002	3	2
LARGE_INTESTINE	METTL4 →	+0.613	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ZNF436 →	+0.600	+3.743	.001	<.001	3	2
LARGE_INTESTINE	LLGL1 →	+0.694	+2.628	.007	.002	3	2
LARGE_INTESTINE	THAP9 →	+0.574	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 797 associations by consensus.

CFC1B by ERBB3 expression — BLOOD_Lymphoma

Explore this box plot interactively →