ERBB2

Across TCGA patient cohorts, ERBB2 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,844 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERBB2-associated proteins across cancer lineages are GRB7, ERBB2_S1083, and FKBP11. Each is linked with ERBB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ERBB2-to-partner and partner-to-ERBB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERBB2 versus GRB7 in BRCA, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB2→partner) and Y-score (partner→ERBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GRB7 →	+1.402	+2.385	<.001	<.001	3	8
BRCA	ERBB2_S1083 →	+0.933	+1.094	<.001	<.001	3	7
LUAD	FKBP11 →	-0.560	-0.731	<.001	<.001	3	5
GBM	TOM1L1 →	+0.576	+0.844	<.001	<.001	3	5
GBM	CTNNA1 →	+0.333	+0.699	.008	.002	3	5
BRCA	ACACA →	+0.606	+1.648	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,844 associations by consensus.

ERBB2 vs GRB7 — BRCA

Explore this scatter interactively →