ERBB2

Across TCGA patient cohorts, ERBB2 mutation is significantly associated with the RNA expression of many other genes, with 4,458 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERBB2-associated genes across cancer lineages are SMIM4, CDC25A, and TYMS. Each is linked with ERBB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERBB2-to-partner and partner-to-ERBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM4 grouped by ERBB2-low versus ERBB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB2→partner) and Y-score (partner→ERBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMIM4 →	+0.425	+2.002	<.001	<.001	3	5
UCEC	CDC25A →	+0.633	+3.374	<.001	<.001	3	4
UCEC	TYMS →	+0.760	+2.445	<.001	<.001	3	4
UCEC	PARP3 →	+0.411	+1.923	.001	.001	3	4
UCEC	REXO5 →	+0.314	+2.882	.003	<.001	3	4
UCEC	MCM6 →	+0.479	+2.502	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,458 associations by consensus.

SMIM4 by ERBB2 expression — UCEC

Explore this box plot interactively →