ERBB2

Across TCGA patient cohorts, ERBB2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERBB2-associated genes across cancer lineages are AMPK_alpha, MSH2, and c-Met_pY1235. Each is linked with ERBB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERBB2-to-partner and partner-to-ERBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_alpha grouped by ERBB2-low versus ERBB2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB2→partner) and Y-score (partner→ERBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AMPK_alpha →	+0.218	+1.907	.025	.031	3	3
UCEC	MSH2 →	-0.213	-1.781	.001	.024	3	3
UCEC	c-Met_pY1235 →	+0.047	+1.257	.028	.027	3	3
UCEC	JNK_pT183_Y185 →	-0.147	-1.777	.002	.001	3	2
UCEC	PCNA →	+0.214	+1.688	<.001	.001	3	2
UCEC	AR →	-0.217	-1.115	.046	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

AMPK_alpha by ERBB2 expression — BRCA

Explore this box plot interactively →