ERBB2

Across TCGA cell cohorts, ERBB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,498 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERBB2-associated GO terms across cancer lineages are ERBB3 signaling pathway, ERBB2-ERBB3 signaling pathway, and Schwann cell differentiation. Each is linked with ERBB2 in more than 16 cancer types. Because this analysis shows association rather than direction, both ERBB2-to-partner and partner-to-ERBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERBB3 signaling pathway grouped by ERBB2-low versus ERBB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB2→partner) and Y-score (partner→ERBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ERBB3 signaling pathway →	+0.223	+1.246	<.001	<.001	3	17
BONE	ERBB2-ERBB3 signaling pathway →	+0.223	+1.246	<.001	<.001	3	17
KIDNEY	Schwann cell differentiation →	+0.149	+1.074	<.001	<.001	3	12
BLOOD_Leukemia	Negative regulation of urine volume →	+0.575	+0.407	<.001	.005	3	12
SOFT_TISSUE	ERBB2-ERBB4 signaling pathway →	+0.488	+1.294	.002	.001	3	12
KIDNEY	Schwann cell development →	+0.145	+1.137	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,498 associations by consensus.

ERBB3 signaling pathway by ERBB2 expression — BONE

Explore this box plot interactively →