ERBB2

Across TCGA cell cohorts, ERBB2 mutation is significantly associated with the RNA expression of many other genes, with 175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERBB2-associated genes across cancer lineages are TBX5, POM121L12, and FAM205A. Each is linked with ERBB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERBB2-to-partner and partner-to-ERBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX5 grouped by ERBB2-low versus ERBB2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERBB2→partner) and Y-score (partner→ERBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBX5 →	+0.162	+4.095	<.001	.003	3	2
LUNG_NSCLC_LUAD	POM121L12 →	+0.012	+3.944	<.001	.006	3	2
LARGE_INTESTINE	FAM205A →	+0.012	+2.252	.007	.005	3	2
LUNG_NSCLC_LUSC	MRGPRX1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	EDDM3A →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ODF4 →	+0.046	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 175 associations by consensus.

TBX5 by ERBB2 expression — OVARY

Explore this box plot interactively →