Across TCGA patient cohorts, ERAS mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERAS-associated genes across cancer lineages are p38-MAPK_pT180_Y182, MAPK_pT202_Y204, and Notch1. Each is linked with ERAS in more than 1 cancer types. Because this analysis shows association rather than direction, both ERAS-to-partner and partner-to-ERAS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAS→partner) and Y-score (partner→ERAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.737	-3.308	.001	.010	3	2
UCEC	MAPK_pT202_Y204 →	-0.537	-3.000	.029	.036	3	1
UCEC	Notch1 →	+0.156	+2.817	.034	.036	3	1
UCEC	FoxM1 →	+0.278	+3.321	.040	.010	1	1
UCEC	p62 Lck ligand →	+0.440	+3.321	.009	.010	1	1
UCEC	TFRC →	+0.988	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

ERAS survival (RNA) · tumor vs normal (RNA) · all ERAS data types