ERAP2

Across TCGA patient cohorts, ERAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,835 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ERAP2-associated GO terms across cancer lineages are Peptide catabolic process, Antigen processing and presentation of peptide antigen via MHC class I, and Antigen processing and presentation of endogenous antigen. Each is linked with ERAP2 in more than 28 cancer types. Because this analysis shows association rather than direction, both ERAP2-to-partner and partner-to-ERAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptide catabolic process grouped by ERAP2-low versus ERAP2-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP2→partner) and Y-score (partner→ERAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Peptide catabolic process →	+0.053	+1.750	<.001	<.001	2	29
SKCM	Antigen processing and presentation of peptide antigen via MHC class I →	+0.047	+1.807	<.001	<.001	3	27
ESCA	Antigen processing and presentation of endogenous antigen →	+0.061	+1.257	<.001	<.001	2	26
ESCA	Antigen processing and presentation of endogenous peptide antigen →	+0.070	+1.445	<.001	<.001	2	26
SCLC	Type II interferon-mediated signaling pathway →	+0.202	+1.573	<.001	<.001	2	26
SCLC	Antigen processing and presentation of peptide antigen →	+0.217	+1.205	.003	.005	1	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,835 associations by consensus.

Peptide catabolic process by ERAP2 expression — UCS

Explore this box plot interactively →