ERAP2

Across TCGA patient cohorts, ERAP2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,898 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ERAP2-associated genes across cancer lineages are APOBEC3C, CEP68, and ENAH. Each is linked with ERAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERAP2-to-partner and partner-to-ERAP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERAP2 versus APOBEC3C in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP2→partner) and Y-score (partner→ERAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APOBEC3C →	+0.735	+0.591	<.001	.009	3	3
UCEC	CEP68 →	-0.388	-0.996	.004	.003	3	3
UCEC	ENAH →	-0.560	-1.013	<.001	.001	3	3
GBM	RN7SL834P →	+0.562	+0.999	.006	<.001	3	3
COAD	GIMAP4 →	+0.610	+0.655	.005	.004	3	2
OV	CTSL →	+0.881	+2.782	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,898 associations by consensus.

ERAP2 vs APOBEC3C — BRCA

Explore this scatter interactively →