ERAP2

Across TCGA patient cohorts, ERAP2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERAP2-associated genes across cancer lineages are Notch1, EGFR, and Annexin_VII. Each is linked with ERAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERAP2-to-partner and partner-to-ERAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ERAP2-low versus ERAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP2→partner) and Y-score (partner→ERAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.175	+2.598	<.001	.005	3	3
UCEC	EGFR →	-0.175	-1.321	.001	.029	3	2
UCEC	Annexin_VII →	-0.139	-2.690	.002	.006	3	2
UCEC	14-3-3_beta →	-0.088	-1.308	.008	.030	3	1
UCEC	eIF4E →	+0.144	+3.183	.042	.009	3	1
UCEC	eIF4G →	+0.279	+3.459	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Notch1 by ERAP2 expression — UCEC

Explore this box plot interactively →