ERAP2

Across TCGA cell cohorts, ERAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,743 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ERAP2-associated GO terms across cancer lineages are Peptide catabolic process, Antigen processing and presentation of endogenous peptide antigen via MHC class I, and Positive regulation of interleukin-4-mediated signaling pathway. Each is linked with ERAP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both ERAP2-to-partner and partner-to-ERAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptide catabolic process grouped by ERAP2-low versus ERAP2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP2→partner) and Y-score (partner→ERAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Peptide catabolic process →	+0.207	+2.324	.002	.003	3	16
BREAST	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.254	+1.602	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of interleukin-4-mediated signaling pathway →	+1.056	+1.590	<.001	<.001	3	12
SOFT_TISSUE	Antigen processing and presentation of peptide antigen via MHC class I →	+0.191	+1.424	<.001	.004	2	13
BREAST	Antigen processing and presentation of endogenous peptide antigen →	+0.245	+1.621	<.001	<.001	3	12
BONE	Peptide antigen transport →	+1.186	+1.596	.008	.004	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,743 associations by consensus.

Peptide catabolic process by ERAP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →