ERAP2

Across TCGA cell cohorts, ERAP2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ERAP2-associated genes across cancer lineages are ACSM6, TCF21, and OR10R2. Each is linked with ERAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERAP2-to-partner and partner-to-ERAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by ERAP2-low versus ERAP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP2→partner) and Y-score (partner→ERAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.021	+3.584	<.001	.002	3	2
BLOOD_Leukemia	TCF21 →	+0.015	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.412	+3.551	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	OR52H1 →	+0.023	+3.084	<.001	.002	3	1
LARGE_INTESTINE	PTTG2 →	+0.069	+3.497	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ACSM6 by ERAP2 expression — LARGE_INTESTINE

Explore this box plot interactively →