ERAP2

Across TCGA cell cohorts, ERAP2 mutation is significantly associated with the mutation status of many other genes, with 4,943 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERAP2-associated genes across cancer lineages are CELF4, FBXO38, and DENND2B. Each is linked with ERAP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERAP2-to-partner and partner-to-ERAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELF4 grouped by ERAP2-low versus ERAP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP2→partner) and Y-score (partner→ERAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CELF4 →	+5.277	+4.459	.005	.005	1	4
BLOOD_Lymphoma	FBXO38 →	+4.584	+4.584	.007	.007	1	4
SKIN	DENND2B →	+4.239	+5.053	.007	.007	1	4
BLOOD_Lymphoma	SREBF1 →	+5.584	+5.014	.003	.003	1	4
BLOOD_Leukemia	MYBPC3 →	+3.341	+3.341	.001	.001	1	4
BLOOD_Leukemia	ZBED4 →	+2.814	+3.282	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,943 associations by consensus.

CELF4 by ERAP2 expression — CNS

Explore this box plot interactively →