ERAP1

Across TCGA patient cohorts, ERAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,688 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERAP1-associated genes across cancer lineages are PSMB9, ETV7, and IL2RB. Each is linked with ERAP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERAP1-to-partner and partner-to-ERAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERAP1 versus PSMB9 in BRCA, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP1→partner) and Y-score (partner→ERAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PSMB9 →	+1.428	+0.695	<.001	<.001	3	7
BRCA	ETV7 →	+1.325	+0.475	<.001	<.001	3	6
BRCA	IL2RB →	+1.110	+0.546	.001	<.001	3	6
OV	SLC15A3 →	+1.250	+0.553	<.001	<.001	3	6
BRCA	IRF1 →	+1.077	+0.664	<.001	<.001	3	6
BRCA	PTPN7 →	+1.058	+0.581	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,688 associations by consensus.

ERAP1 vs PSMB9 — BRCA

Explore this scatter interactively →