ERAP1

Across TCGA patient cohorts, ERAP1 mutation is significantly associated with the RNA expression of many other genes, with 2,604 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERAP1-associated genes across cancer lineages are KRTAP20-3, MIR1298, and RNU6-1188P. Each is linked with ERAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERAP1-to-partner and partner-to-ERAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP20-3 grouped by ERAP1-low versus ERAP1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP1→partner) and Y-score (partner→ERAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRTAP20-3 →	+0.148	+7.954	<.001	.008	3	2
HNSC	MIR1298 →	+0.323	+7.954	<.001	.008	3	2
CESC	RNU6-1188P →	+0.276	+3.996	<.001	.005	3	2
KIRP	LINC02107 →	+0.094	+5.628	<.001	.004	3	2
KIRP	IGKV3D-31 →	+0.122	+6.103	<.001	.002	3	2
KIRP	LINC01070 →	+0.022	+5.376	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,604 associations by consensus.

KRTAP20-3 by ERAP1 expression — HNSC

Explore this box plot interactively →