ERAP1

Across TCGA patient cohorts, ERAP1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERAP1-associated genes across cancer lineages are ATM, eIF4E, and ERK2. Each is linked with ERAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERAP1-to-partner and partner-to-ERAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ERAP1-low versus ERAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP1→partner) and Y-score (partner→ERAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.527	-2.169	<.001	<.001	3	3
UCEC	eIF4E →	+0.142	+1.765	.030	.013	3	2
UCEC	ERK2 →	+0.212	+2.392	<.001	<.001	3	2
UCEC	GAPDH →	+0.340	+1.584	.041	.017	3	2
UCEC	JNK_pT183_Y185 →	-0.187	-2.392	<.001	<.001	3	2
UCEC	Lck →	+0.174	+2.000	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by ERAP1 expression — UCEC

Explore this box plot interactively →