ERAL1

Across TCGA patient cohorts, ERAL1 mutation is significantly associated with the RNA expression of many other genes, with 2,378 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERAL1-associated genes across cancer lineages are BUB3, DPH3, and EME1. Each is linked with ERAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERAL1-to-partner and partner-to-ERAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by ERAL1-low versus ERAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAL1→partner) and Y-score (partner→ERAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.481	+2.156	<.001	.009	3	2
UCEC	DPH3 →	+0.417	+2.625	.004	.005	3	2
UCEC	EME1 →	+0.552	+3.364	.003	.004	3	2
UCEC	BUB1B →	+0.813	+2.595	.001	<.001	3	2
UCEC	PKN3 →	+0.704	+3.491	<.001	.002	3	2
UCEC	MED27 →	+0.338	+2.151	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,378 associations by consensus.

BUB3 by ERAL1 expression — UCEC

Explore this box plot interactively →