ERAL1

Across TCGA cell cohorts, ERAL1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERAL1-associated genes across cancer lineages are GSG1L2, IFNG, and PRKAG3. Each is linked with ERAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERAL1-to-partner and partner-to-ERAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by ERAL1-low versus ERAL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAL1→partner) and Y-score (partner→ERAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
BLOOD_Leukemia	IFNG →	+0.220	+4.152	<.001	.009	3	1
BLOOD_Leukemia	PRKAG3 →	+0.045	+4.551	<.001	.004	3	1
BLOOD_Leukemia	MMP20 →	+0.061	+4.705	<.001	.003	3	1
BLOOD_Leukemia	CNGB3 →	+0.101	+4.152	.007	.009	3	1
BLOOD_Leukemia	DEFB4A →	+0.159	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GSG1L2 by ERAL1 expression — LARGE_INTESTINE

Explore this box plot interactively →