EPYC

Across TCGA pan-cancer cohorts, EPYC Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EPYC data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher EPYC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated EPYC expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

STAD, UCEC, and LUAD are the cancer types where EPYC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	III,IV	0.074	0.629	<.001	18	view →
UCEC	DFS	Median	All	1.000	0.630	.038	4	view →
LUAD	OS	Median	All	1.000	0.338	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

EPYC–STAD (OS)

Open the STAD breakdown →