EPYC

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, EPYC protein abundance is significantly associated with the RNA expression of many other genes, with 7,769 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EPYC-associated genes across cancer lineages are DCBLD1, TIMP3, and TAF7L. Each is linked with EPYC in more than 2 cancer types. Because this analysis shows association rather than direction, both EPYC-to-partner and partner-to-EPYC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPYC versus DCBLD1 in PDAC, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPYC→partner) and Y-score (partner→EPYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACDCBLD1 →+0.899+1.273.002.00433
OVTIMP3 →+1.718+0.527<.001<.00132
PDACTAF7L →+0.411+1.445<.001<.00132
OVCOMP →+3.448+0.615<.001<.00132
OVPCOLCE →+1.475+0.486.008.00632
OVAEBP1 →+2.034+0.496<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 7,769 associations by consensus.

EPYC vs DCBLD1 — PDAC

Per-sample scatter of EPYC vs DCBLD1 in PDAC (Pearson r = 0.77).

Explore this scatter interactively →

Exploration