EPYC

Across TCGA patient cohorts, EPYC mutation is significantly associated with the RNA expression of many other genes, with 1,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPYC-associated genes across cancer lineages are SNHG30, SMC5-AS1, and SNTB2. Each is linked with EPYC in more than 1 cancer types. Because this analysis shows association rather than direction, both EPYC-to-partner and partner-to-EPYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNHG30 grouped by EPYC-low versus EPYC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPYC→partner) and Y-score (partner→EPYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNHG30 →	+0.719	+2.593	<.001	.006	3	2
UCEC	SMC5-AS1 →	+0.543	+3.346	<.001	.005	3	2
SKCM	SNTB2 →	+0.700	+3.331	.009	.005	3	2
SKCM	TMEM192 →	+0.631	+3.604	.004	.001	3	2
SKCM	PDP2 →	+0.696	+3.616	<.001	.001	3	2
SKCM	UROS →	+0.594	+2.517	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,512 associations by consensus.

SNHG30 by EPYC expression — UCEC

Explore this box plot interactively →