EPYC

Across TCGA cell cohorts, EPYC mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible EPYC-associated genes across cancer lineages are C16orf90, PRODH2, and HCRT. Each is linked with EPYC in more than 1 cancer types. Because this analysis shows association rather than direction, both EPYC-to-partner and partner-to-EPYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf90 grouped by EPYC-low versus EPYC-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPYC→partner) and Y-score (partner→EPYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C16orf90 →	+0.036	+4.467	<.001	.004	3	1
SKIN	PRODH2 →	+0.037	+4.095	.002	.009	3	1
LUNG_NSCLC_LUAD	HCRT →	+0.091	+2.980	<.001	.007	3	1
LUNG_NSCLC_LUAD	LCN15 →	+0.508	+3.466	<.001	.005	3	1
LARGE_INTESTINE	ZNF831 →	+0.011	+3.425	<.001	<.001	3	1
LARGE_INTESTINE	CENPVL3 →	+0.212	+2.657	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C16orf90 by EPYC expression — SKIN

Explore this box plot interactively →