EPYC

Across TCGA cell cohorts, EPYC mutation is significantly associated with the mutation status of many other genes, with 1,503 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPYC-associated genes across cancer lineages are EPHA3, SLC12A3, and ALDH1L1. Each is linked with EPYC in more than 2 cancer types. Because this analysis shows association rather than direction, both EPYC-to-partner and partner-to-EPYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPHA3 grouped by EPYC-low versus EPYC-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPYC→partner) and Y-score (partner→EPYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EPHA3 →	+4.807	+4.807	.008	.008	1	3
STOMACH	SLC12A3 →	+4.807	+4.807	.008	.008	1	3
LUNG_SCLC	ALDH1L1 →	+4.066	+5.022	.001	.001	1	3
LUNG_SCLC	C1QTNF2 →	+5.066	+4.502	.007	.007	1	3
SKIN	SPTBN1 →	+2.924	+4.724	<.001	<.001	1	3
SKIN	LHCGR →	+3.094	+4.850	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,503 associations by consensus.

EPHA3 by EPYC expression — STOMACH

Explore this box plot interactively →