EPX

Across TCGA patient cohorts, EPX mutation is significantly associated with the RNA expression of many other genes, with 1,783 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPX-associated genes across cancer lineages are RNA5SP509, MRPL58, and TAF9. Each is linked with EPX in more than 2 cancer types. Because this analysis shows association rather than direction, both EPX-to-partner and partner-to-EPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP509 grouped by EPX-low versus EPX-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPX→partner) and Y-score (partner→EPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP509 →	+0.113	+5.141	<.001	.001	3	3
SKCM	MRPL58 →	+0.360	+2.938	.006	<.001	3	3
UCEC	TAF9 →	+0.410	+1.874	<.001	.002	3	3
UCEC	TMEM126A →	+0.292	+1.539	.002	.004	3	3
UCEC	RNF126 →	+0.479	+2.401	<.001	<.001	3	3
UCEC	RAPGEF4 →	-0.305	-1.411	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,783 associations by consensus.

RNA5SP509 by EPX expression — HNSC

Explore this box plot interactively →