EPX

Across TCGA patient cohorts, EPX mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPX-associated genes across cancer lineages are 14-3-3_beta, Caspase-7-cleavedD198, and eIF4E. Each is linked with EPX in more than 2 cancer types. Because this analysis shows association rather than direction, both EPX-to-partner and partner-to-EPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EPX-low versus EPX-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPX→partner) and Y-score (partner→EPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.235	-2.974	.027	.036	3	3
UCEC	Caspase-7-cleavedD198 →	+0.393	+1.785	.035	.007	3	3
UCEC	eIF4E →	+0.198	+3.598	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.099	-1.986	.035	.029	3	2
UCEC	Akt_pT308 →	+0.461	+1.765	.020	.011	3	2
UCEC	p90 RSK →	+0.121	+1.512	.043	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

14-3-3_beta by EPX expression — COAD

Explore this box plot interactively →