EPX

Across TCGA cell cohorts, EPX RNA expression is significantly associated with the go_rna of many other GO terms, with 1,940 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible EPX-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Regulation of syncytium formation by plasma membrane fusion, and Cilium-dependent cell motility. Each is linked with EPX in more than 9 cancer types. Because this analysis shows association rather than direction, both EPX-to-partner and partner-to-EPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by EPX-low versus EPX-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPX→partner) and Y-score (partner→EPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.119	+0.136	<.001	<.001	3	10
PANCREAS	Regulation of syncytium formation by plasma membrane fusion →	+0.094	+0.040	<.001	.001	3	9
OVARY	Cilium-dependent cell motility →	-0.063	-0.072	.001	.009	3	9
OVARY	Cilium or flagellum-dependent cell motility →	-0.063	-0.072	.001	.009	3	9
PANCREAS	Regulation of myoblast fusion →	+0.092	+0.042	<.001	.001	3	9
KIDNEY	Sperm motility →	-0.109	-0.046	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,940 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by EPX expression — LUNG_SCLC

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