EPSTI1

Across TCGA patient cohorts, EPSTI1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPSTI1-associated genes across cancer lineages are Notch1, INPP4B, and JNK2. Each is linked with EPSTI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPSTI1-to-partner and partner-to-EPSTI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by EPSTI1-low versus EPSTI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPSTI1→partner) and Y-score (partner→EPSTI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.273	+3.713	<.001	<.001	3	2
UCEC	INPP4B →	-0.278	-2.321	.043	.033	3	1
UCEC	JNK2 →	+0.293	+2.594	<.001	.006	3	1
UCEC	Ku80 →	+0.233	+2.820	.020	.035	3	1
UCEC	MSH2 →	-0.308	-2.295	.001	.033	3	1
UCEC	p21 →	+0.182	+2.906	.026	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by EPSTI1 expression — UCEC

Explore this box plot interactively →