EPSTI1

Across TCGA cell cohorts, EPSTI1 mutation is significantly associated with the mutation status of many other genes, with 3,283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPSTI1-associated genes across cancer lineages are FAM124B, KDM1A, and BCL7C. Each is linked with EPSTI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPSTI1-to-partner and partner-to-EPSTI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM124B grouped by EPSTI1-low versus EPSTI1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPSTI1→partner) and Y-score (partner→EPSTI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM124B →	+4.044	+5.000	.008	.008	1	3
CNS	KDM1A →	+6.044	+6.044	.001	.001	1	3
CNS	BCL7C →	+6.044	+6.044	.001	.001	1	3
LARGE_INTESTINE	DMC1 →	+4.744	+5.459	<.001	<.001	1	3
LARGE_INTESTINE	NAA25 →	+3.422	+4.807	<.001	<.001	1	3
LARGE_INTESTINE	GNB3 →	+3.744	+4.044	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,283 associations by consensus.

FAM124B by EPSTI1 expression — CNS

Explore this box plot interactively →