Across TCGA pan-cancer cohorts, EPS8L3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EPS8L3 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EPS8L3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EPS8L3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where EPS8L3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.743	0.413	<.001	92	view →
CCRCC	OS	Median	All	0.793	1.000	.009	17	view →
UCEC	OS	Median	II,III,IV	1.000	0.671	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: EPS8L3 tumor-vs-normal RNA expression · all EPS8L3 data types